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Tart cherry juice for arthritis11/23/2023 ![]() For example, one 8 oz bottle of a tart cherry juice blend is equivalent to 50 cherries. 23 In addition to raw cherries, numerous cherry products including juices, powders, concentrates, and extracts are commercially available. 14 The stage of ripening, among other things, plays a role in the content of potentially therapeutic compounds found in cherries, with ascorbic acid, total phenolics, antioxidant activity, and total anthocyanins increasing as the fruit ripens. The most commonly grown cultivar of sweet cherry in the US is the Bing, while the most common for tart cherry is the Montmorency cherry. 22 Cherries are typically grouped into two major categories, sweet ( Prunus avium) and tart/sour ( Prunus cerasus). The recognition of antioxidant and anti-inflammatory properties of cherries has prompted numerous studies examining their benefits in patients with gout, 16 insomnia, 17 muscle endurance and recovery, 18 and potential benefit in cardiovascular disease, 19, 20 diabetes, 20, 21 and cancer. Cherries contain vitamins A, C, E, and phenolics such as anthocyanins 14, 15 ( Table 1). The cherry is a small nutrient-rich fruit garnering a great deal of attention as a nonpharmacologic option for the treatment of a multitude of disease manifestations in recent years. 12, 13 This implies that additional treatment options for gout, including complementary medicines such as cherries, are of high interest to patients and possibly to healthcare providers as well. 11 Patients also prefer disease self-management strategies such as diet modification, exercise, weight reduction, medication self-management, as well as use of natural therapies as management options for their chronic diseases. 10 Providers and patients believe that more ULT options are needed, since a proportion of patients with gout cannot be treated with the currently available ULTs due to low medication adherence, contraindications, inefficacy or partial efficacy, or adverse events. 7 An internet-based survey of patients with self-reported, physician-diagnosed gout found that 24% preferred cherry extract as a potential means for chronic ULT. Qualitative research suggests that approximately a quarter of gout patients use cherry products (cherries, cherry extract, or cherry juice) to treat their gout. 7 Therefore, it is no wonder that many patients afflicted with gout find themselves seeking complementary or alternative therapies. 8, 9 In fact, patients ranked interaction of gout medication with medications for other medical conditions as one of their biggest concerns when treating gout. Patients with gout often have a multitude of comorbidities, 4 – 6 leading to concern over drug–drug interactions and medication adverse events 7 including skin rash, gastrointestinal side effects, infusion reactions, and rare life-threatening hypersensitivity reactions to certain gout drugs. 3 Several urate-lowering therapies (ULTs) successfully decrease the burden of gout however, they are not without potential risks. Once thought of as the disease of kings, gout has a prevalence of 3.9% in the US, affecting 8.3 million adults, 1, 2 with a doubling of incidence seen in both men and women over the past 20 years. ![]() ![]() Gout is a chronic and often debilitating disease associated with recurrent flares of inflammatory arthritis, manifesting as severe pain and joint dysfunction, which, if untreated, can lead to joint damage and significant morbidity. In this review, we explore the potential benefits of cherries and cherry products as a nonpharmacologic option for the treatment of gout. Based on these properties, cherries may reduce both the acute and chronic inflammation associated with recurrent gout flares and its chronic destructive arthropathy. ![]() Perhaps a quarter of patients with gout try cherries or cherry products to treat their gout, which have antioxidant and anti-inflammatory (IL-6, TNF-α, IL-1β, IL-8, COX-I and -II) properties, hypouricemic effects, and the ability to downregulate NFkB-mediated osteoclastogenesis. The cherry is a small nutrient-rich fruit that has garnered a great deal of attention in recent years as a nonpharmacologic option for the treatment of a multitude of disease manifestations. Patients with gout often have a multitude of comorbidities, leading to concern over drug–drug interactions and medication adverse events. Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs for the treatment of gout, there is considerable interest in novel treatment approaches. ![]()
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